Telomere-related Genome Instability in Cancer
نویسندگان
چکیده
منابع مشابه
Telomere-related Genome Instability in Cancer
tumor types are in an astonishing state of disarray. The extent of genome scrambling was only appreciated after development of high-resolution techniques. Spectral karyotyping (M-FISH, SKY) has painted a picture of extensive reshuffling of chromosome segments. Techniques that display the differences between normal and cancer genomes, combined with DNA microarrays (array-CGH, Pinkel et al. 1998;...
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Genome instability is a hallmark of most human cancers. Although a mutator phenotype is not required for tumorigenesis, it can foster mutations that promote tumor progression. Indeed, several inherited cancer-prone syndromes are due to mutations in DNA repair pathways. However, sporadic tumors are usually proficient in DNA repair, making it unlikely that unrepaired lesions are a major source of...
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The nucleoprotein complexes that cap the very ends of the eukaryotic chromosomes, named telomeres, are indispensable for cell viability. Telomeric DNA shortens in each cell division until it cannot exert end-protective functions in human somatic cells. Additionally, several proteins have been described to play a key role in telomere homeostasis preventing chromosome extremities to be recognized...
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Defects in the genes encoding the Paf1 complex can cause increased genome instability. Loss of Paf1, Cdc73, and Ctr9, but not Rtf1 or Leo1, caused increased accumulation of gross chromosomal rearrangements (GCRs). Combining the cdc73Δ mutation with individual deletions of 43 other genes, including TEL1 and YKU80, which are involved in telomere maintenance, resulted in synergistic increases in G...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Symposia on Quantitative Biology
سال: 2005
ISSN: 0091-7451,1943-4456
DOI: 10.1101/sqb.2005.70.032